What Exactly is AICAR:
AICAR is a synthetic version of the body’s adenosine monophosphate. While Adenosine monophosphate is a crucial component in many cellular metabolic processes, including the conversion to ADP and ATP, it’s also used to produce RNA.
AMPK activity is stimulated by AICAR, which leads to increased hepatic fatty acid oxidation, ketogenesis, and glucose uptake in skeletal muscle. AICAR also inhibits cholesterol synthesis, lipogenesis, and triglyceride synthesis. AICAR inhibits adipocyte lipogenesis.
What is AICAR Known For?
Properties that Help Build Muscle
Research shows that AICAR has effects on the body that include increased muscle mass and also helps to slow down the onset of muscle wasting as people get older. The study shows that there may be a future use of the AICAR peptide in treating muscle-wasting disorders. In addition, AICAR’s muscle-building effects are amplified when combined with rigorous exercise.
Possibilities for reducing inflammation
Recent clinical trials show that AICAR plays an essential role in cellular inflammation. AICAR’s effects are similar to those of metformin, a well-known diabetes medication with anti-inflammatory properties. Atherosclerosis and asthma are both inflammatory diseases that AICAR protects against. In addition, ACIAR has been shown to reduce inflammation in colitis in studies done on mice. Scientists also believe that AICAR has the potential to mediate the symptoms of autoimmune diseases as well as other inflammatory conditions.
Enhancing the chances of conception
Researchers have found that AICAR, an AMPK activator, can improve sperm motility, metabolism and fertilizing ability in cats, chickens and goats. It has minimal side effects and a high bioavailability in mice. However, AICAR can only be used for research and not for human consumption.
Enhanced Sensitivity to Insulin
Adipose tissue, the connective tissue that stores energy as fat, is less inflammatory when given high or low doses of AICAR, according to studies done on mice. Inflammation in fat is linked to increased insulin resistance. In addition, better glucose homeostasis results from reducing inflammation. AICAR reduces inflammation in adipose tissue by utilizing multiple pathways that involve SIRT1, macrophages, and other immune cells. Weight loss and increased insulin resistance were observed in obese monkeys in yet another study. Furthermore, research from the AICAR Institute has shown that the inflammatory response is suppressed in diabetic and non-diabetic mice. In addition, according to the research, insulin sensitivity and lipid metabolism improved and energy homeostasis and inflammation symptoms.
Preventing Heart Disease
Inflammation is frequently linked to heart disease. Therefore research suggests that vascular diseases can be halted or even reversed with the use of AICAR’s potent anti-inflammatory effects. AICAR was administered to rabbit atherosclerosis models to see what happened. Using AICER, researchers found that vascular smooth muscle proliferation was reduced after the stent was placed in the short and long term. According to the findings of this study, activation of AICAR appears to suppress immune responses that contribute to atherosclerosis. In addition, macrophage proliferation, which can subsequently lead to a heart attack, is caused by bad cholesterol (LDL) accumulation. Thus, AICAR has the potential to slow the spread of heart disease and strokes.
Death of Cancer Cells
Research has shown cancer cells die when the AMPK enzyme is activated for an extended period because their metabolism slows down. AICAR is also being studied in combination with other chemotherapeutic agents by scientists to improve its efficacy. They think AICAR has the potential to:
- Reduce the likelihood of negative side effects.
- Enhance the outcomes of chemo-resistant tumour patients
- Reduce the dosage of these medications.
- AICAR has been found to induce P21 accumulation in thyroid cancer cells, leading to programmed cell death. But, overall, scientists are confident that AICAR can stop cancer cells from multiplying and thriving.
AICAR’s side effects can include the following:
Molar mass: 338.21 g/mol
Unit Quantity: 1 Vial
Appearance: White Powder
Peptide Purity: >99%