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B7-33

B7-33

£15,99

Availability: In stock

Description

B7-33 Peptide Vial 2mg

What Exactly Is B7-33 2mg?

Anti-fibrotic properties of B7-33 are powerful. Fibrosis is a significant problem in many diseases, including heart failure, lung inflammation, kidney disease, and more. B7-33 has been shown to reduce fibrosis by 50%, allowing injured animals to live longer and providing the first new treatment for heart problems in 20 years.

It has been demonstrated to reduce the formation of excessive scar tissue after cardiac injury. In addition, some vascular disorders and preeclampsia during pregnancy have also shown promising results.

Synthetic H2-relaxin, a single-chain peptide derived from the more extensive, naturally occurring protein H2-relaxin, exerts various physiologic and reproductive effects. ERK1/2 phosphorylation, promotion of MMP2 expression, and degradation of extracellular collagen are all promoted by relaxin, which has anti-fibrotic properties without enhancing cAMP production. Four endogenous receptors (RXFP1/2 and RXFP3/4) exist for the relaxin family peptides.

The following is an explanation of how these receptors work:

  • RXFP-1: Critical part in sperm motility, pregnancy, vascular endothelial cells, and joint health.
  • RXFP-2: It appears to be playing a central role in the growth of the testis.
  • RXFP-3 genetic changes are connected to Schizoid personality disorder and particular sleep problems.
  • RXFP-4 has demonstrated that insulin-like peptide 5 plays a vital role in appetite signalling and is expressed in sperm.

Several stimuli can activate relaxin receptors: cAMP; orexin; CRF; insulin-like peptides; GLP-1; and other insulin-like substances. It has been shown that agonists have anti-inflammatory, antioxidative, and wound healing properties. Aside from vasodilator, blood vessel growth stimulator, and antihypertrophic, relaxin has been shown in studies to have all of the other properties listed above. Because of this, this same peptide, as well as its derivatives, can be used to treat acute heart failure and other fibrotic conditions.


Studies: https://pubmed.ncbi.nlm.nih.gov/32295457/


Sequence: VIKLSGRELVRAQIAISGMSTWSKRSL

Unit Quantity: 1 Vial

Appearance: White Powder

Peptide Purity: >99%

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