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Vasoactive Intestinal Peptide

Vasoactive Intestinal Peptide


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Vasoactive Intestinal Peptide 2mg Peptide Vial

What Exactly Is Vasoactive Intestinal Peptide?

Vip has been found to be beneficial in a variety of inflammation-related conditions including neurodegenerative, fibrotic, inflammatory bowel disease, as well as cardiac fibrosis. In several fibrotic pathways, the peptide is considered to be extremely effective and could provide treatment benefits for the popular method of fibrosis that causes such much morbidity and death.

Aside from being a potent antifibrotic agent, VIP is also a powerful immune response controller and general anti-inflammatory agent. Additionally, the peptide was shown to safeguard the central nervous system from damage and is of interest in the treatment of neurodegenerative disease.

What is VIP Known For?

Twenty-eight amino acids make up the vasoactive intestinal peptide. It’s produced by cells in the digestive tract, and it’s recognised as a vasoactive intestinal peptide (VIP). VIP peptides have been shown in animal studies to reduce inflammation. Neurodegenerative disease, inflammatory bowel disease, pulmonary fibrosis, and cardiac fibrosis have all been shown to benefit from its use in animal studies.

In addition to its role as an immune system regulator, the vasoactive intestinal polypeptide is believed by experts to shield the brain and spinal cord from potentially harmful stimuli. Researchers are also involved in preserving cognitive function as the disease progresses.

Studies suggest that certain gastrointestinal hormones may act as neurotransmitters inside the brains of animals, although this function is not fully understood. Glucagon, motilin, somatostatin, and neuropeptide Y are a few examples.

A glucagon superfamily, vasoactive intestinal peptide is found in vertebrates’ gut, brain, and pancreas. In animal studies, this peptide has been shown to stimulate contractility inside the heart, increase the breakdown of glycogen, reduce blood pressure, and soothe the muscles of a gallbladder and stomach.

Several decades ago, scientists discovered that the VIP hormone stimulates the pancreatic juice to produce more water and bile, as evidenced by animal studies.

The following are examples of VIP side effects that have been demonstrated in animal studies:

Viral peptides (VIPs) have been found to relax smooth muscle, increase water secretion into pancreatic juice, and inhibit gastric acid secretion and absorption in animal studies. So for those with colitis or Crohn’s disease, scientists say it can help.

VIP, a peptide, profoundly affects the heart and cardiovascular system. Studies on animals show that this substance stimulates the dilation of coronary arteries, which positively affects the heart’s inotropic and chronotropic systems.

Brain: Animal studies have shown that it can restrict prolactin secretion and stimulate pituitary hormone secretion.

Advantages of Vasoactive intestinal peptide

According to researchers, animal studies have shown that the VIP peptide can reduce inflammatory cytokines. Anti-inflammatory properties of the peptide have also been demonstrated in animal studies of arthritis.

Another study found that VIP, which suppresses TH1 immune responses while promoting TH2-type reactions, is necessary for immune tolerance. Currently, scientists are looking into the possibility that VIP could boost the immune system in animals, decrease macrophage TGF-b1, enhance anti-inflammatory responses, and inhibit TLR4 activation.

Inflammatory bowel diseases, such as Crohn’s and colitis, can be alleviated by VIP, according to a study published in the Journal of Biological Chemistry. Inflammation-suppressing peptide interleukin-10 can be produced by T cells generated by vasoactive intestinal peptides. IBD is thought to be exacerbated by Th1 inflammation.

Improved intestinal barrier function allows scientists to target the root cause of IBD and reduce the severity in animal test subjects by 100.

The vasoactive intestinal peptide is a Neuroprotectant.

Neurotransmitter, neurotrophic/neurogenic, and anti-inflammatory/neuroprotective actions are part of VIP’s central nervous system action. The first step is to keep the animal’s internal barriers in place. It’s important to remember that maintaining the blood-brain wall controls how nutrients, immune cells, and oxygen reach the brain. Stroke, MS, and encephalomyelitis are just a few health problems that can arise if this system is compromised.

According to research, the beta-amyloid buildup in animals with Alzheimer’s disease can be controlled by the VIP peptide hormone. According to scientists, it also has neuroprotective effects on Parkinson’s disease and other related conditions.

A growing body of evidence suggests intestinal polypeptide is an essential brain neuroprotectant that can protect white matter from damage and improve neuron function. In addition, according to animal studies, VIP has anti-inflammatory properties that may help with Parkinson’s disease.

Vasoactive Intestinal Peptide Cardiomyopathy

In many cases, cardiac fibrosis is a final stage in the progression of heart disease. As a result, valve dysfunction, cardiac filling alterations and decreased contractility are possible side effects. A transplant is often necessary for people with fibrosis, as is the case with lung disease. Scar formation is the primary focus of current cardiac research, and several drugs have been developed to slow the scarring-causing process of cardiac remodelling. Unfortunately, low success rates have been reported, with mammal test subjects showing progressing fibrosis and impaired cardiac function.

According to new research, in rats, VIP peptides have been shown to slow down and reverse scarring. A decrease in angiotensinogen and angiotensin receptor type 1a expression, which also slows down cardiac modelling and fibrosis, is to blame scientists.

COPD with a high level of personalisation

There are two ways that Vasoactive Intestinal Peptide affects lung function. To begin, it involves inflammation-induced pulmonary vascular remodelling. The peptide NFAT, which is responsible for activating T cells and increasing inflammation, is suppressed in this process. By controlling lung inflammation in the first place, VIP helps to keep diseases like COPD at bay. As a result, researchers believe VIP treatment may help patients avoid the need for a lung transplant in the final stages of their disease.

Second, VIP peptide slows down the growth of smooth muscle cells, which is a long-term effect of lung inflammation. According to new research, VIP peptides may also control blood pressure in the pulmonary arteries. As a result of this, cardiac output and oxygen capacity increase.

Studies: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743256/


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