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MOTS-C is a mitochondrial peptide that has been shown to extend life expectancy, promote metabolic homeostasis, and reduce obesity in studies. In addition, because it is a member of the more prominent family of mitochondrial-derived peptides (MDPs), scientists believe this short peptide is critical in energy control and mitochondrial communication.
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MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a peptide derived from the mitochondrial genome, playing a crucial role in metabolic regulation. It consists of 16 amino acids and influences cellular energy balance by modulating pathways such as insulin sensitivity, ATP synthase activity, and calcium homeostasis. MOTS-C For Sale is part of a growing field focused on the discovery of unique peptides encoded by the mitochondrial genome, such as Humanin, which also holds potential therapeutic applications.
MOTS-C promotes autophagy, mitophagy, and reduces apoptosis, aiding in tissue repair and immune regulation. It interacts with metabolic pathways, matrix metalloproteinases, the ubiquitin-proteasome system, and even immune checkpoints. Its ability to regulate these processes positions it as a potential therapeutic target for conditions related to metabolic disorders, inflammation, and oxidative stress.
Recent advances in technologies, such as SPR (Surface Plasmon Resonance) and in vivo dissolution calculators, are shedding light on MOTS-C’s primary target organs and mechanisms. For example, studies suggest its influence on the basement membrane, which could play a role in tissue integrity and repair. Additionally, its interaction with methionine adenosyltransferase pathways further enhances its relevance in cellular metabolism and energy regulation.
The growing body of research highlights MOTS-C For Sale as a promising area of focus in metabolic and immune-related studies.
Source: PubChem
MOTS-C helps regulate metabolism by targeting processes related to energy production, glucose use, and stress responses.
1. Regulation of Glucose Metabolism
MOTS-C can improve how skeletal muscle cells handle glucose by activating the AMP-activated protein kinase (AMPK) pathway. AMPK is an important enzyme that helps balance energy in cells. Its activation promotes glucose uptake and fat breakdown, especially during metabolic stress. By influencing AMPK, MOTS-C For Sale may help cells use energy more effectively.
2. Adaptation to Cellular Stress
MOTS-C activates responses that help cells adapt during times of low energy, such as during calorie restriction. It protects cells from oxidative stress and damage, mimicking natural stress-response mechanisms. This makes it an important area of research in understanding how cells manage stress.
3. Support for Mitochondrial Function
Mitochondria are the cell’s energy producers, and their efficiency is essential for cell health. MOTS-C For Sale is thought to support mitochondrial repair and replacement, keeping them functioning properly. This helps maintain energy production and overall cellular health.
MOTS-C is a relatively new peptide in research. While findings are promising, these observations are from preclinical studies and are not yet validated in human trials.
1. Metabolic Health
MOTS-C may help maintain metabolic balance. Studies suggest it could improve glucose metabolism, providing valuable insights for diabetes research, especially in areas like insulin resistance and glucose uptake.
2. Ageing and Longevity
Mitochondrial problems are linked to many age-related conditions. Researchers are studying MOTS-C For Sale for its ability to regulate stress and support mitochondrial repair, which could help in understanding cellular ageing and longevity.
3. Exercise Performance
In animal studies, MOTS-C For Sale has been shown to improve physical endurance. It appears to make metabolism more efficient during exercise, making it an interesting subject in sports physiology research.
4. Cellular Protection
Research on MOTS-C is still in the early stages, and there is no available data on side effects in humans. Preclinical studies have not shown significant adverse effects, but more research is needed to identify any potential risks.
MOTS-C is strictly for laboratory and experimental use. Researchers must follow all ethical and legal guidelines when working with research peptides. Proper handling and administration procedures are essential to ensure the safety of all personnel involved. MOTS-C For Sale from My Peptides are for research use only.
Molecular Formula: C101H152N28O22S2
Molar weight: 2174.6
Sequence: H-Met-Arg-Trp-GlnGlu-Met- Gly-Tyr-Ile-Phe-TyrPro-Arg-Lys-Leu-Arg-OH
Unit Quantity: 1 Vial
Appearance: White Powder
Peptide Purity: >99%
[1] Zheng Y, Wei Z, Wang T. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Front Endocrinol (Lausanne). 2023 Jan 25;14:1120533.
[2] Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Int J Mol Sci. 2022 Oct 9;23(19):11991.
[3] Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021 Jan 20;12(1):470.
[4] Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015 Mar 3;21(3):443-54.
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