MOTS-C

Description

What Exactly is MOTS-C:

MOTS-C is a mitochondrial peptide that has been shown to extend life expectancy, promote metabolic homeostasis, and reduce obesity in studies. In addition, because it is a member of the more prominent family of mitochondrial-derived peptides (MDPs), scientists believe this short peptide is critical in energy control and mitochondrial communication.

The nucleus of a cell contains a large number of MDPs, according to new research. When they enter the bloodstream, many of them have an impact all over the body.

A growing body of evidence suggests that it has a role to play in metabolic processes as well as age-related diseases like diabetes and osteoporosis.

Intensive research into the MOTS-C peptide’s capabilities has been going on for the last five years.

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What is MOTS-C Known For?

Insulin Resistance:
Scientists believe the peptide could be an effective biomarker for pre-diabetic people who are overweight. They also think that changes in MOTS-C levels may indicate a change in insulin sensitivity in the body.

As a result, MOTS-C supplementation may aid in preventing human type 1 diabetes and insulin resistance.

More clinical trials are needed to learn more about the effects of mots c in humans, even though research in mice models is promising.

Fat Loss:
Scientists discovered a few years ago that the MOTS-C hormone effectively prevented weight gain that was brought on by a high-fat Western diet. As a result, scientists were ecstatic to learn that it has the ability to target muscle tissue and mitigate diet-induced insulin resistance specifically. Using a high-fat diet to induce obesity and insulin resistance in mice, one study administered a MOTS-C injection. For MOTS-C, the injection suppressed both behavioural and pharmacological outcomes in mice.

According to current research, it appears that dysregulation of fat metabolism in mitochondria may result in a lack of fat oxidation, which raises levels of circulating fat and forces the body to increase insulin levels to remove lipids from the bloodstream.

This increases fat storage and a change in homeostasis in the body, which becomes less responsive to insulin at higher concentrations.

Cardiovascular Health:
A study of people undergoing coronary angiography who had low levels of MOTS-C found that those patients had higher levels of endothelial cell dysfunction.

A healthy circulatory system relies on endothelial cells to keep blood clotting and plaque formation under control. According to new findings in rats, MOTS c sensitizes endothelial cells and thus improves endothelial function and blood vessel function.

While MOTS-C is an effective peptide for improving heart health, it is not the only one. According to the research, at least three MDPs are shown to be important in protecting cardiac cells from inflammation and stress.

Because of this, scientists believe MDP dysregulation contributes significantly to the development of cardiovascular disease.

Osteoporosis:
A study found that MOTS-c treatment increased the distance that mice of all ages could run compared to untreated mice. As a result, the older the mouse, the better it performed in the test. Thus, MOTS c peptide may improve exercise capacity at the cellular level, according to this study.

Osteoblasts in the bone are activated by the MOTS-C peptide, according to research. This helps with type I collagen synthesis. Why? It controlled the TFG-beta SMAD pathways, which aid osteoblast health and survival. Because MOTS-C promotes osteoblast survival, it aids in the production of type 1 collagen, which in turn improves bone strength.

The peptide promotes bone marrow stem cell differentiation via the same pathway as osteoporosis, according to additional research into the disease’s effects and MOTS c. As a result, new bone was formed, which is referred to as increased osteogenesis.

Results show that MOTS-c protects osteoblast health and survival while also encouraging osteoblast differentiation from stem cells.

Due to growing research, over-the-counter MOTS-C medication for osteoporosis treatment and prevention may be available in the coming months or years.

Anti-Ageing:
MOTS-c is a peptide that has been linked to increased human longevity in scientific studies.

The study discovered a specific alteration in the peptide in Japanese people associated with longer life expectancy. Research, on the other hand, shows that it affects everyone.

The MOTS-c gene mutation causes a glutamate residue to be substituted in the lysine protein at position 14, where it usually would not be. Currently, scientists are unsure of the impact of this alteration on the protein’s functional elements. However, glutamate differs significantly from lysine in terms of properties, so they are confident it does. More research is needed to determine the full impact of this change on function. According to research, it can only be found in people from the Northeast Asian region.

Researchers believe that human longevity can be extended through the study of mitochondrial biology. The mitochondria are implicated in a wide range of age-related pathogens as an essential metabolic organelle. To extend the life and improve overall health, researchers are looking into the potential of peptides like MOTS-C.

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Studies:

https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC4350682/

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Effects:

MOTS-C peptide has been shown through research to have several health benefits, which are detailed below:

• Insulin resistance is a thing of the past with this supplement.
• Increases the metabolic flexibility of the body.
• Increases the rate of weight loss.
• Activates a protein that aids in the regulation of mitochondrial energy.
• Increases the body’s ability to handle physical stress.
• Enhances the body’s ability to regulate glucose.
• Osteoporosis treatment and prevention are made more accessible with this supplement.

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Formula: C101H152N28O22S2

Molar mass: 2174.6

Sequence: H-Met-Arg-Trp-GlnGlu-Met- Gly-Tyr-Ile-Phe-TyrPro-Arg-Lys-Leu-Arg-OH

Unit Quantity: 1 Vial

Appearance: White Powder

Peptide Purity: >99%