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MOTS-C is a mitochondrial peptide that has been shown to extend life expectancy, promote metabolic homeostasis, and reduce obesity in studies. In addition, because it is a member of the more prominent family of mitochondrial-derived peptides (MDPs), scientists believe this short peptide is critical in energy control and mitochondrial communication.
$31.65 – $142.43
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MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is an amino acid peptide derived from the mitochondrial DNA genome, playing a crucial role as part of a group of peptides involved in metabolic regulation and offering potential health benefits. [1]
It consists of 16 amino acids and is a member of the larger group of mitochondrial peptides that have a significant impact on cellular function, energy metabolism, and energy balance by modulating pathways such as insulin sensitivity, ATP synthase activity, and calcium homeostasis.
MOTS-C For Sale is part of a growing field focused on unique peptides encoded by the mitochondrial genome, such as Humanin, which also holds potential therapeutic applications.
MOTS-C promotes autophagy, mitophagy, and reduces apoptosis, aiding in tissue repair and immune regulation. It interacts with metabolic pathways, nuclear gene expression, fatty acids, the ubiquitin-proteasome system, and even immune checkpoints.
Additionally, it plays a role in endothelial function and impacts endothelial cells, which is important for preventing coronary endothelial dysfunction. Its ability to regulate these processes positions it as a potential therapeutic target for conditions related to metabolic disorders, inflammation, and oxidative stress.
Recent advances in technologies, such as SPR (Surface Plasmon Resonance) and in vivo dissolution calculators, are shedding light on MOTS-C’s primary target organs and mechanisms. For example, studies suggest its influence on the basement membrane, which could play a role in tissue integrity and repair.
MOTS-C may also impact mesenchymal stem cells and the differentiation of bone marrow stem cells, enhancing tissue regeneration. Additionally, its interaction with methionine adenosyltransferase pathways further enhances its relevance in cellular metabolism and energy regulation.
The growing body of research highlights MOTS-C For Sale as a promising area of focus in metabolic and immune-related studies, with research from Lee et al and the USC Leonard Davis School of Gerontology showing promising results.
Source: PubChem
MOTS-C can improve how skeletal muscle cells handle glucose by activating the AMPK kinase pathway. AMPK is an important enzyme that helps balance energy in cells. Its activation promotes glucose uptake, expression of glucose transporters, and fat breakdown, especially during metabolic stress. [2]
1. Regulation of Glucose Metabolism
MOTS-C can improve how skeletal muscle cells handle glucose by activating the AMPK kinase pathway. AMPK is an important enzyme that helps balance energy in cells. Its activation promotes glucose uptake, expression of glucose transporters, and fat breakdown, especially during metabolic stress. [3]
By influencing AMPK, MOTS-C For Sale may help cells use energy more effectively and improve muscle uptake of glucose, supporting muscle growth and muscle function.
2. Adaptation to Cellular Stress
MOTS-C also helps cells adapt to stress, especially in situations of glucose restriction or dietary restriction. It helps protect cells from oxidative stress and damage, mimicking natural stress-response mechanisms.
This makes it an important area of research for understanding how cells manage stress. MOTS-C For Sale may also play a role in functional insulin resistance, which is a key factor in the development of diabetes.
3. Support for Mitochondrial Function
Mitochondria are the cell’s energy factories, and their efficiency is essential for cell health. MOTS-C supports mitochondrial repair and replacement, keeping them functioning properly. This helps maintain energy production and overall cellular health.
Additionally, fat metabolism and the regulation of fatty acids support proper mitochondrial function. Hepatic mitochondrial dysfunction may also be improved by MOTS-C For Sale, further emphasizing its potential for treating metabolic disorders.
By influencing these processes, MOTS-C For Sale may help regulate how energy is used in challenging conditions, offering insight into muscle metabolism and aging. Researchers are studying its potential for managing metabolic disorders, age-related diseases, and development of diabetes.
MOTS-C may help maintain metabolic balance with precision. Studies suggest it could improve glucose metabolism, providing valuable insights for diabetes research, especially in areas like insulin regulation and glucose uptake. It may also enhance fat metabolism and help the body use energy more effectively, which could be crucial in muscle metabolism and fatty acid processing.
1. Metabolic Health
MOTS-C may help maintain metabolic balance with precision. Studies suggest it could improve glucose metabolism, providing valuable insights for diabetes research, especially in areas like insulin regulation and glucose uptake, ultimately aiding in better management of blood sugar levels. [4]
2. Ageing and Longevity
Mitochondrial problems are linked to many age-related conditions. [5] Researchers are studying MOTS-C for its ability to regulate stress and support mitochondrial repair, which could help in the study of metabolic health and deepen our understanding of mitochondrial function, understanding cellular aging, longevity, and the complex processes of MDP dysregulation.
Dietary restriction has been shown to increase the expression of mitochondrial peptides like MOTS-C, which may offer clues about aging and the maintenance of nuclear genomes over time.
3. Exercise Performance
In animal studies, MOTS-C For Sale has improved physical endurance. It appears to make metabolism more efficient during exercise, making it an interesting subject in sports physiology research. Enhancing muscle metabolism and muscle function may also help improve muscle growth and performance. [6]
4. Cellular Protection
Research on MOTS-C is still in the early stages, and there is no available data on side effects in humans. Preclinical studies have not shown significant adverse effects, but more research opportunities are needed to identify any potential risks and better understand its potential roles. As a pure peptide, MOTS-C For Sale operates at the cellular level, influencing key processes like fat metabolism and muscle metabolism.
MOTS-C For Sale is strictly for laboratory research and experimental use. Licenced researchers must follow all ethical and legal guidelines when working with it. It’s available in lyophilized peptide form from My Peptides for research use only.
When reconstituted, it can be used to study its impact on synthesis processes, which could enhance our understanding of the body’s ability to regulate energy. The peptide may eventually be incorporated part of a regimen to improve physical performance, though further research is needed.
Molecular Formula: C101H152N28O22S2
Molar weight: 2174.6
Sequence: H-Met-Arg-Trp-GlnGlu-Met- Gly-Tyr-Ile-Phe-TyrPro-Arg-Lys-Leu-Arg-OH
Unit Quantity: 1 Vial
Appearance: White Powder
Peptide Purity: >99%
[1] Zheng Y, Wei Z, Wang T. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Front Endocrinol (Lausanne). 2023 Jan 25;14:1120533.
[2] Yang B, Yu Q, Chang B, Guo Q, Xu S, Yi X, Cao S. MOTS-c interacts synergistically with exercise intervention to regulate PGC-1α expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway. Biochim Biophys Acta Mol Basis Dis. 2021 Jun 1;1867(6):166126.
[3] Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metab. 2018 Sep 4;28(3):516-524.e7.
[4] Gao Y, Wei X, Wei P, Lu H, Zhong L, Tan J, Liu H, Liu Z. MOTS-c Functionally Prevents Metabolic Disorders. Metabolites. 2023 Jan 13;13(1):125.
[5] Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Int J Mol Sci. 2022 Oct 9;23(19):11991.
[6] Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021 Jan 20;12(1):470.
[7] Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015 Mar 3;21(3):443-54.
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